Comparative pathological study on the therapeutic effect of camel’s milk, turmeric extract and cisplatin on induced hepatocarcinogenesis in rats

Abstract

This study was carried out in order to investigate the possible therapeutic effect of camel milk on induced hepatocarcinogenesis in rats and comparably with other antitumor agent either natural or chemical. Ninety six male rats were assigned into two groups (48 rats per group). Group 1 served as a non treated control. Group 2 was injected I/P with diethylnitrosamine (DENA) (200 mg/kg) as a single dose and after one week received 500 ppm phenobarbitone in drinking water for 28 weeks. Three rats from each group were euthanized at the 19th week and 28th week to follow up the progress of hepatocarcinogenesis. At 28th week, each group was subdivided into six groups. Group A served as a control negative group. Group B treated with camel milk. Group C treated with camel milk and turmeric extract. Group D treated with turmeric extract. Group E treated with cisplatin. Group F treated with cisplatin and camel milk. Group G was injected with DENA (control positive group). Group H was injected with DENA and treated with camel milk (5ml/day). Group I was injected with DENA and treated with camel milk and turmeric extract (250 mg/kg). Group J was injected with DENA and treated with turmeric extract.