Sick Euthyroid Syndrome In Prevalent Hemodialysis Patients

Abstract

Chronic renal failure (CRF) is an irreversible deterioration of renal function, including impairment of excretory, metabolic and endocrine functions of the kidney leads to development of clinical syndrome of uremia. CKD affects thyroid function in many ways, including low circulating thyroid hormone levels, altered peripheral hormone metabolism, insufficient binding to carrier proteins, reduced tissue thyroid hormone content and altered iodine storage in the thyroid gland. Chronic kidney disease (CKD) causes alterations in thyroid hormones in the absence of an underlying intrinsic thyroid disorder, known as the sick euthyroid syndrome. We aimed to study the frequency of sick euthyroid syndrome in prevalent hemodialysis patients. The study included 40 patients on regular hemodialysis randomly selected from Ain Shams University hospital dialysis unit, all patients were on regular hemodialysis thrice weekly for at least 6 months, each dialysis session will last four hours. The studied population had a mean of age is 38.9 years, male patients were 21 (52.5%), the mean of hemodialysis duration were 7 ± 4.8 years. All patients were subjected to assessment of different clinical and laboratory parameter including full assessment of thyroid gland anatomical and functional state.