IN VITRO EFFECT OF RECOMBINANT IL-2 ON CYTOTOXIC T LYMPHOCYTE IN PATIENTS WITH HEAD AND NECK CANCER

Abstract

Immunotherapy is a new modality for cancer treatment aiming . to int nsify the compromized immune system of the patients to get. I .

rid of'

their cancers. As head and neck cancer is one of the most

sophifticated problem met with in ENT clinics, this in vitro study was designed to assess the possibility of applying this therapy in I vivo ater on. This was guided by the findings that the in vitro parameters of lymphocyte activation have been used as possible predi tors of the in vivo effectiveness of immunotherapy. Cytokines ! grouJ:i is one of the most effective agents used for this purpose,

espec1

1 I

y riL-2.

The present study revealed that riL-2 is patent stimulus for IL- 2R elpression on CDS T lymphocyte. It also could effectively stimJlate NK proliferation. When lymphocytes were stimulated by I Con lt\, IL-2 could be detected in the supernatant. Lastely, it was I revea)ed the presence of high frequency of lymphomas possibly due

to lol, socioeconomic status, the prevalence of parasitic and viral I Infections.