Prognostic Implication and Markers of Risk After Acute Anterior Myocardial Infarction • A Comparison Between Clinical, Laboratory, Resting and Stress Tissue Doppler Echocardiography Variables

Abstract

The prognosis after acute myocardial infarction depends on multiple and interrelated factors. Effective risk stratification is integral to the management of patients with ST-segment elevation acute myocardial infarction.

This study aimed to assess and compare •the prognostic implication of clinical and laboratory variables, and resting and stress echocardiographic variables in patients with first acute uncomplicated anterior myocardial infarction.

The present study included 159 patients who were admitted m Cardiology Department, Tanta University Hospital, from June 2002 to April 2005. One hundred and twenty nine of these patients had first acute anterior uncomplicated myocardial infarction treated with thrombolytic therapy within 6 hours from the onset of chest pain. The remaining thirty patients were age and sex matched healthy adults without history of heart disease or systemic hypertension, and having normal resting electrocardiographic and echocardiographic findings. They were considered as a control group .

All these patients were subjected at admission and during hospitalization to careful history analyses, full clinical examination, resting standard twelve leads electrocardiogram, and some laboratory analysis including admission high sensitive C-reactive protein, admission total leukocytes count, peak monocyte level ,peak creatine kinase, peak creatine kinase-MB levels, complete lipid profile, and fasting and post-prandial blood sugar. Before discharge, these patients were also subjected to resting