Evaluation of the role of mixture of fish and corn oils in repression of induced Ulcerative colitis in rats

Abstract

Ulcerative colitis is an inflammatory bowel disease that characterized by chronic and relapsing inflammation of the gastrointestinal tract. The exact etiology of the disease is still not fully elucidated, as many factors are contributed in the disease pathogenesis. Dysregulated immune response toward luminal bacteria that highly triggered by environmental factors in genetically susceptible individuals is the most accepted mechanism. It has been reported by previous studies that dietary management may be an interesting alternative or complementary to drug therapy to prevent or induce remission in UC patients, if it proves to be effective without side effects. One of the attracted food type in this research field is polyunsaturated fatty acids (PUFA). Polyunsaturated fatty acids (PUFA) can be classified into two major categories, namely ω-3 and ω-6, which are present as essential cellular components and possess diverse biofunctions. PUFAs are essential fatty acids that should be obtained from diet as the body could not synthesize them endogenously. Pathogen-free adult male Swiss albino rats weighing 200±20g were acclimatized for 7 days and then separated into four groups each of ten rats.