Effect of Silica Oxide Nanoparticles on Liver of Adult Male Albino Rat. Light and Electron Microscopic Study.

Abstract

Currently, nanoparticles (NPs) are considered a great scientific revolution due to their different applications. They are characterized by size ranging between 1 and 100 nanometers. They have unique physicochemical properties regarding chemical composition, surface structure, solubility, shape and aggregation. Silica oxide NPs (SiO2 NPs) in particular, have received increasing interest due to their unique characteristics that led to their wide utilization in biomedicine, pharmaceuticals and other industrial manufacturing fields. However, nanoparticles (NPs) can potentially cause adverse effects on organ, tissue, cellular, subcellular, and protein levels due to their unusual physicochemical properties. As a result, there are many challenges to overcome before scientists can determine if the benefits outweigh the risks associated with NPs use. The aim of this study was to assess the effect of different doses and durations of intravenous injections of SiO2 NPs on the hepatic tissue structure of adult male albino rats.