Mechanism of Disintegrin/like domain in Mesenchymal Stem Cells Homing to Mice Liver Injury Model

Abstract

This study was done at the Research Unit of Natural Toxins, Medical Biochemistry Department, Ain Shams University Faculty of Medicine. Experimental design was assigned to include5 groups of white albino mice. The aim of this study was to assess the molecular mechanism of disintegrin/ like domain on labeled bone marrow mesenchymal stem cell recruitment & homing into CCl4 induced injured liver and evaluate its effect & stem cell ability to regenerate functioning hepatocytes through comparative measuring of liver functions (serum ALT, AST, and serum albumin levels) as well as relative quantitative assessment of gene expression to the followings (stromal derived factor-1α(SDF-1α), hepatocyte growth factor (HGF), transforming growth factor beta 1 (TGF-β1) and CXCR4 genes) using real time PCR.