Management of Thrombotic Microangiopathy overlap syndrome: A clinical trial

Abstract

There are many obstetric, medical, and surgical disorders that share many of the clinical and laboratory findings of patients with severe pre-eclampsia–eclampsia. Imitators of severe pre-eclampsia and eclampsia are life-threatening emergencies that can develop during pregnancy or in the postpartum period. These conditions are associated with high maternal and perinatal mortalities and morbidities and survivors may face long-term sequelae. Differential diagnosis may be difficult due to the overlap of several clinical and laboratory findings of these syndrome. When dealing with differential diagnoses of preeclampsia complicated by severe HELLP syndrome, it is relatively easy to decide rapidly for AFLP, SLE and APS, but sometimes it can be difficult, almost impossible, to differentiate it from multi-organ failure linked with severe sepsis or TTP/HUS due to TMA. The dilemma of differentiating between HELLP, AFLP and TTP and HUS in a patient presenting with evidence of hemolysis, DIC, elevated liver enzymes and renal impairment is still ongoing due to the limited evidences for differences between them. The distinction of