MELANOCYTIC NEVI AND MELANOMAS: DIAGNOSTIC AND PROGNOSTIC EVALUATION BY NUCLEOLAR ORGANISER REGIONS AND IMAGE CYTOMETRY
Naglaa Mohamed El S ayed Mohamed;
Abstract
The present work was carried out to evaluate the value of
dermoscopy, as a non invasive technique in the diagnosis and differential
!
diagnosis of melanocytic skin tumors from other pigmented skin lesions
as well as to assess the diagnostic and prognostic roles of AgNORs and image cytometry in melanocytic tumors.
To achieve these goals, 233 cases presented with pigmented skin tumors in outpatient's clinic, AleFaculty of Medicine. They were subjected to clinical, dermoscopic and histopathologic diagnoses. I 00 cases were selected for AgNOR staining and image cytometry to include all variants of benign nevi (39 cases), all cases of malignant melanoma (14 cases) and only 47 cases of common acquired nevi (selected according to recent change in the morphology, history of chronic sun exposure or occurrence of repeated inflammation).
The clinical diagnosis showed concordance with the histopathologic diagnosis in 80.3% with clinical sensitivity of92.3% for detecting melanocytic nevi and 100% for detecting malignant melanoma.
On the other hand the dermoscopic examination showed concordance with the histopathologic diagnosis in 85% with 97.9% sensitivity for detecting melanocytic nevi and I 00% for detecting malignant melanoma.
In the present study, it was observed that some derrnoscopic patterns were seen m both melanocytic and non melanocytic lesions as pigment network, homogenous pigmentation, telangiectasia, yellow dots and leaf like pigmentation.
dermoscopy, as a non invasive technique in the diagnosis and differential
!
diagnosis of melanocytic skin tumors from other pigmented skin lesions
as well as to assess the diagnostic and prognostic roles of AgNORs and image cytometry in melanocytic tumors.
To achieve these goals, 233 cases presented with pigmented skin tumors in outpatient's clinic, AleFaculty of Medicine. They were subjected to clinical, dermoscopic and histopathologic diagnoses. I 00 cases were selected for AgNOR staining and image cytometry to include all variants of benign nevi (39 cases), all cases of malignant melanoma (14 cases) and only 47 cases of common acquired nevi (selected according to recent change in the morphology, history of chronic sun exposure or occurrence of repeated inflammation).
The clinical diagnosis showed concordance with the histopathologic diagnosis in 80.3% with clinical sensitivity of92.3% for detecting melanocytic nevi and 100% for detecting malignant melanoma.
On the other hand the dermoscopic examination showed concordance with the histopathologic diagnosis in 85% with 97.9% sensitivity for detecting melanocytic nevi and I 00% for detecting malignant melanoma.
In the present study, it was observed that some derrnoscopic patterns were seen m both melanocytic and non melanocytic lesions as pigment network, homogenous pigmentation, telangiectasia, yellow dots and leaf like pigmentation.
Other data
| Title | MELANOCYTIC NEVI AND MELANOMAS: DIAGNOSTIC AND PROGNOSTIC EVALUATION BY NUCLEOLAR ORGANISER REGIONS AND IMAGE CYTOMETRY | Other Titles | تقييم الوحمات الصبغية والأورام الملانية باستخدام مناطق التنظيم النووى والعد الخلوى للحامض النووى | Authors | Naglaa Mohamed El S ayed Mohamed | Issue Date | 2001 |
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