Serum Transforming Growth Factor beta 2 in Breast-fed versus Hydrolyzed formula-fed preterm Neonates
Abdel-Rahem Ahmed Abdel-Rahem Hamed;
Abstract
SUMMARY
W
e hypothesis that Breast Fed (BF) preterm neonates exhibit higher level of serum TGF-β2 and lower incidence of Feeding Intolerance (FI) compared to HPF preterm neonates.
We conducted a prospective, observational study in the period from 6/2015 to 7/2016 on 80 preterm neonates <36 wks at El Gameia El Shareia NICU, Sohag.
It aimed to assess the occurance of FI and NEC in preterm neonates and its relation to serum TGF-β2 in BF versus HPF fed neonates.
Eighty preterm neonates were enrolled. Inclusion criteria were GA ≤ 36 weeks. Exclusion criteria were the presence of any contraindication to feeding (e.g. GIT surgical condition), inborn error of metabolism, chromosomal abnormalities or congenital malformation. They allocated equally in 2 groups (BF group and HPF fed group).
BF group included 40 preterm neonates among which 50% were female. Mean for birth weight was 1.72 kg, mean for GA was 32.8 wks, 70% were delivered via CS.
As for the HPF group, among the 40 neonates included, 47.5% were female, 67.5% was born to CS. Mean for birth weight was 1.67kg while mean for GA was 32.5 weeks.
All study subjects received their usual care and medications according to the treating physicians, protocols of management. Additionally, trophic feeding was started (10-20 ml/kg/day) with daily increment of (10-20 ml/kg/day) if feeds were tolerated.
Study subjects were followed up daily till they were discharged or died. Daily measurement of weight, feeding protocol of all subjects was recorded, type of milk, daily increment of feeding, frequency of feeding intolerance, and stoppage of feeding for any stage of NEC (staging and diagnosis were done according to Bell's criteria), Frequency of septic episodes, respiratory support needed. Serum TGF-β2 level was measured (when baby reached 75 ml/kg/day).
Overall incidence of NEC was 2 out of total 80 neonates (2.5%), all were in HPF group and no NEC occurred in BF group. Lower GA and birth weight were a risk factors. FI was found in 24 out of total 80 (30%), 9 of them (22.5%) were in BF group, and 15(37.5%) were in HPF group.
W
e hypothesis that Breast Fed (BF) preterm neonates exhibit higher level of serum TGF-β2 and lower incidence of Feeding Intolerance (FI) compared to HPF preterm neonates.
We conducted a prospective, observational study in the period from 6/2015 to 7/2016 on 80 preterm neonates <36 wks at El Gameia El Shareia NICU, Sohag.
It aimed to assess the occurance of FI and NEC in preterm neonates and its relation to serum TGF-β2 in BF versus HPF fed neonates.
Eighty preterm neonates were enrolled. Inclusion criteria were GA ≤ 36 weeks. Exclusion criteria were the presence of any contraindication to feeding (e.g. GIT surgical condition), inborn error of metabolism, chromosomal abnormalities or congenital malformation. They allocated equally in 2 groups (BF group and HPF fed group).
BF group included 40 preterm neonates among which 50% were female. Mean for birth weight was 1.72 kg, mean for GA was 32.8 wks, 70% were delivered via CS.
As for the HPF group, among the 40 neonates included, 47.5% were female, 67.5% was born to CS. Mean for birth weight was 1.67kg while mean for GA was 32.5 weeks.
All study subjects received their usual care and medications according to the treating physicians, protocols of management. Additionally, trophic feeding was started (10-20 ml/kg/day) with daily increment of (10-20 ml/kg/day) if feeds were tolerated.
Study subjects were followed up daily till they were discharged or died. Daily measurement of weight, feeding protocol of all subjects was recorded, type of milk, daily increment of feeding, frequency of feeding intolerance, and stoppage of feeding for any stage of NEC (staging and diagnosis were done according to Bell's criteria), Frequency of septic episodes, respiratory support needed. Serum TGF-β2 level was measured (when baby reached 75 ml/kg/day).
Overall incidence of NEC was 2 out of total 80 neonates (2.5%), all were in HPF group and no NEC occurred in BF group. Lower GA and birth weight were a risk factors. FI was found in 24 out of total 80 (30%), 9 of them (22.5%) were in BF group, and 15(37.5%) were in HPF group.
Other data
| Title | Serum Transforming Growth Factor beta 2 in Breast-fed versus Hydrolyzed formula-fed preterm Neonates | Other Titles | مقارنة تركيز عامل النمو المحول بيتا 2 في الدم بين الرضاعة بحليب الأم و الحليب المحلل فى الأطفال الخدج | Authors | Abdel-Rahem Ahmed Abdel-Rahem Hamed | Issue Date | 2016 |
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