A Retrospective Analysis of Epidemiological and Prognostic Factors of Non Small Cell Lung Cancer

Abstract

L ung cancer is one of the commonest and most lethal cancers throughout the world. Among the subtypes of lung cancer, non-small cell lung cancer (NSCLC) is the most prevalent, accounting for 85% of all new cases. The epidemiological and pathological profile varies among different ethnicities and geographical regions. While there have been advances in therapeutic options, a significant unmet medical need remains. There have been small gains in NSCLC survival rates; however, the significance of these gains and the benefits to patients with a variety of characteristics are unclear. The aim of the study was to analyze the current clinico-pathological profile and factors affecting survival of non small cell lung cancer patients at the department of Clinical Oncology and Nuclear medicine in Ain Shams University hospitals. Data from records of 195 pathologically confirmed non small cell lung cancer cases were available for clinicopathological analysis during the study period. The mean age at diagnosis of the study population was 59 years, Male to female ratio was 3.6:1, 71.2% of cases were current or x-smokers, majority of reported cases were living in urban areas, 44.6% of patients had ECOG performance status 1, 41% of patients gave history of medical co morbidity such as diabetes mellitus, hepatitis B or C viral infection or hypertension.