SOME PHARMAC OLOGICAL PROPERTIES OF MAEBOFLOXACIN
Ahmed Saad Mousa Khalil;
Abstract
The present work was a trial to study the effect of marbofloxacin on the reproductive system in male Albino rats. Moreover, some biochemical parameters and histopathological changes were also examined.
Forty five mature male Albino rats weighing from 140- 180 gm each of 4- 5
month old were used in this study.
The animals were divided into 3 equal groups each of 15 rats. The first and second groups were injected 11M for 5 consecuative days with marbofloxacin at the dose level of 7.2 mg I Kg B.Wt and 14.4 mg I Kg B.Wt. respectively. The third group was kept as control and injected 11M with 0.3 mL saline I rat for 5 consecutive days.
The obtained results showed that adminstration of marbofloxacin induced a variety of adverse effects. These are represented by certain fertility troubles as reduction of testes, epididymis and accessory sex organs weights, changes in sperm characters ( decrease of sperm count and motility ) and decrease of serum testosterone level. Moreover, the liver and kidney functions were significantly affected. Therefore, caution is required when using large doses of the drug of marbofloxacin due to its adverse effect on the sperrn characters, liver and kidneys.
Marbofloxacin is a fluoroquinolones that commonly used as the antimicrobial agent against Haemophilus paragallinarum, Pasteruel/a species, E.coli, Salmonella species, Mycoplasma species, Staphylococus species and Erysipelothrix rhusiopathiae by the selective inhibition of the enzyme DNA gyrase, which is necessary for the synthesis ofbacterial DNA.
Forty five mature male Albino rats weighing from 140- 180 gm each of 4- 5
month old were used in this study.
The animals were divided into 3 equal groups each of 15 rats. The first and second groups were injected 11M for 5 consecuative days with marbofloxacin at the dose level of 7.2 mg I Kg B.Wt and 14.4 mg I Kg B.Wt. respectively. The third group was kept as control and injected 11M with 0.3 mL saline I rat for 5 consecutive days.
The obtained results showed that adminstration of marbofloxacin induced a variety of adverse effects. These are represented by certain fertility troubles as reduction of testes, epididymis and accessory sex organs weights, changes in sperm characters ( decrease of sperm count and motility ) and decrease of serum testosterone level. Moreover, the liver and kidney functions were significantly affected. Therefore, caution is required when using large doses of the drug of marbofloxacin due to its adverse effect on the sperrn characters, liver and kidneys.
Marbofloxacin is a fluoroquinolones that commonly used as the antimicrobial agent against Haemophilus paragallinarum, Pasteruel/a species, E.coli, Salmonella species, Mycoplasma species, Staphylococus species and Erysipelothrix rhusiopathiae by the selective inhibition of the enzyme DNA gyrase, which is necessary for the synthesis ofbacterial DNA.
Other data
| Title | SOME PHARMAC OLOGICAL PROPERTIES OF MAEBOFLOXACIN | Other Titles | بعض خواص الفارماكولوجية للمربوفلوكساسين | Authors | Ahmed Saad Mousa Khalil | Issue Date | 2011 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| Ahmed Saad Mousa Khalil.pdf | 1.47 MB | Adobe PDF | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.