Prediction and Prevention of Pregnancy Induced Hypertension
Amira Mahmoud EL-Emary;
Abstract
Hypertension is the most common medical complication of pregnancy. Pre-eclampsia is a pregnancy-specific, multiorganic syndrome and a major cause of maternal morbidity and perinatal morbidity and mortality.
Preeclampsia: IS characterized by vasospasm and coagulation abnormalities. The etiology of preeclampsia is unlmown. Numerous theories and factors have been suggested to explain its cause, but most of them were not confrrrned. Some theories that are still under COf!Sideration included an immunologic disorder, a genetic disorder and abnormal placentation. A delicate balance between the maternal immune responses and the fetal genotype appears to regulate the process of trophoblastic invasion that is necessary for normal placentation. A disturbance in this balance may be responsible for the development of preeclampsia.
Preeclampsia is associated with an imbalance in the production of
prostaglandins with deficient intravascular production of prostacyclin and with excessive production of thromboxane A2. There is also evidence of activation of the clotting system and early involvement of platelets.
Many different screening tests have been proposed for the prediction of preeclampsia. To be good, a screening test should be sensitive, reliable, cheap and easy to perform. The sCf!Sitivity and predictive values of the tests vary considerably. However, screening is only worthwhile if there is an effective intervention available to prevent the disease or improve outcome.
Preeclampsia: IS characterized by vasospasm and coagulation abnormalities. The etiology of preeclampsia is unlmown. Numerous theories and factors have been suggested to explain its cause, but most of them were not confrrrned. Some theories that are still under COf!Sideration included an immunologic disorder, a genetic disorder and abnormal placentation. A delicate balance between the maternal immune responses and the fetal genotype appears to regulate the process of trophoblastic invasion that is necessary for normal placentation. A disturbance in this balance may be responsible for the development of preeclampsia.
Preeclampsia is associated with an imbalance in the production of
prostaglandins with deficient intravascular production of prostacyclin and with excessive production of thromboxane A2. There is also evidence of activation of the clotting system and early involvement of platelets.
Many different screening tests have been proposed for the prediction of preeclampsia. To be good, a screening test should be sensitive, reliable, cheap and easy to perform. The sCf!Sitivity and predictive values of the tests vary considerably. However, screening is only worthwhile if there is an effective intervention available to prevent the disease or improve outcome.
Other data
| Title | Prediction and Prevention of Pregnancy Induced Hypertension | Other Titles | التنبؤ ومنع حدوث ارتفاع ضغط الدم المصاحب للحمل | Authors | Amira Mahmoud EL-Emary | Issue Date | 2001 |
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