Acute kidney injury in ICU patients, relation with intra-abdominal hypertension

Abstract

Thepresent study wasconducted on40ICUinpatientsatAinShamsUniversity HospitalsintheperiodfromMarch 2012to September 2012.The40includedpatientswere dividedinto2 groups20 patientseach: Group1:patientswhohadacutekidneyinjury[AKI]. Group2: patientswhodidnothaveacutekidneyinjury[AKI]. All patients were subjected to intra-vesical pressure measurementonadmissionandfollowupafter48hoursfrom ICUadmission.

Both IVP0 (intra-vesical pressure on ICU admission) and IVP1 (intra-vesical pressure after 48 hours from ICU admission) showed statistically significant differencebetween the AKI and non AKI groups.

In AKI group, there was significant positive correlation between IVP1and serum Creatinine on ICU admission (Cr0), serum Creatinine after 48 hours from ICU admission ( Cr1) , serum Creatinine on discharge from ICU (Cr2),HB and BMI.Besides,therewasstatistically significantpositivecorrelation between IVP1 and exposure to surgery,sepsis,renal replacementtherapyandascites.

Meanwhile in AKI group,therewas significantnegativecorrelationbetween IVP1 and AST, INR,PH on ICU admission, PHafter 48 hours from ICU admission andHCO3on ICU admission.

There was a strong positive correlation between IVP as a marker of IAH and development of AKI in ICU patients.

Measuring IVP in the first day of the study was able to predict the development of AKI.

Repeating IVP measurement did not show superiority over the first evaluation for prediction of AKI.