Diagnostic and Prognostic Significance of Deletion 20q12, Trisomy 8 and Trisomy 9 . in cMPDs Patients
Hend Mamdouh Sayed;
Abstract
Cytogenetic and molecular analyses have provided support for the current pathogenetic model of philadelphia positive and negative myeloproliferative neoplasms (MPNs). Genetic profiling of MPNs has the aim to improve the diagnosis and subclassification of these hematological malignancies, and most important, may lead to a significant improvement in assignment of therapeutic protocols.
Genetic analysis of MPNs identified Ph chromosome, trisomy 8, trisomy 9 and del 20q as the most frequent non random genetic aberrations encountered in MPN. Therefore, this study aimed to detect these chromosomal abnorma lities in MPN s pat ients, and to assess their prognostic significance on patients' outcome.
Genetic analysis of MPNs identified Ph chromosome, trisomy 8, trisomy 9 and del 20q as the most frequent non random genetic aberrations encountered in MPN. Therefore, this study aimed to detect these chromosomal abnorma lities in MPN s pat ients, and to assess their prognostic significance on patients' outcome.
Other data
| Title | Diagnostic and Prognostic Significance of Deletion 20q12, Trisomy 8 and Trisomy 9 . in cMPDs Patients | Other Titles | الدلاله التشخيصية والتكهن بمآل المرض لفقدان جزء من الذراع الطويل لكروموسوم 20 والتعدد الثلاثى للكروموسوم 8و9 فى امراض اضطرابات التكاثر النقوى المزمن | Authors | Hend Mamdouh Sayed | Issue Date | 2011 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| هند ممدوح سيد.pdf | 212.73 kB | Adobe PDF | View/Open |
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