Anti-HLA antibodies production and nitric oxide level in the serum and urine of post renal transplant patients in relation to renal graft function and survival

Abstract

Renal transplantation is considered the treatment of choice for most ESRD patients, all patients with ESRD are considered candidates for renal transplantation unless they have systemic malignancy, chronic infections, severe cardiovascular diseases or neuropsychiatry disorders. Renal transplantation can be performed before patients requiring dialysis. Ultimately the patients is responsible for choosing between dialysis and transplantation as options for renal replacement therapy.

Detection of anti-HLA antibodies in the serum of post renal transplant patients allows identification of high risk recipients with poor graft outcome which could provide guidance for immunosuppression therapy and improve the success of anti-rejection therapy.

The aim of the present work was to study the production of anti­ liLA antibodies and nitric oxide level and serum and urine of post renal transplant patients in relation to renal graft function and survival.