Macrophage Inflammatory Protein-1 alpha in Gingival Crevicular Fluid and Placental Tissues in Chronic Periodontitis Patients with Preterm Delivery



Preterm birth is a worldwide perinatal problem and has evident public health implications; their incidence doesn’t decrease in spite of the many attempts at their prevention. Both intra-uterus infections and bacterial vaginosis of the mother are among known risk factors, but even subclinical distant infections may also produce preterm births (Farrell et al., 2006; Àgueda et al., 2008). The present study was conducted on forty patients to assess the possible correlation between chronic periodontitis and preterm delivery. Patients were categorized into four groups 10 mothers each; Group I included mothers undergoing spontaneous preterm delivery and having moderate to severe chronic periodontitis, while Group II included mothers undergoing spontaneous preterm delivery and having healthy periodontium. Mothers undergoing spontaneous term delivery at ≥37 weeks of gestation without any obstetrical or medical complications whether having moderate to severe chronic periodontitis or healthy periodontium were categorized in Group III and IV respectively. For each participant both placental tissue and gingival crevicular sample were obtained and the mean concentration levels of macrophage inflammatory protein-1α in gingival crevicular fluid and in placental tissue homogenate were determined in each patient and correlated with periodontal clinical parameters. No statistically significant difference between the mean of MIP1-α in GCF in different study groups. However its concentration was higher in healthy periodontium groups than in chronic periodontitis groups regardless the time of delivery. While the mean MIP l-α level in placenta was high in chronic periodontitis group than healthy periodontium groups. The mean concentration of MIP-1α in placental tissues in term was higher than its concentration in preterm and the difference was statistically significant. The positive correlation that was found between MIP1-α mean concentration in GCF and periodontal clinical parameters; CAL, PD and PI while negatively correlated was with GI in contrast to MIP1-α mean concentration in placenta. And the negative correlation that was observed between MIP1-α mean concentration in placenta and both mean concentration in GCF and gestational duration. Within the limitation of this study design and sample size although our finding cannot prove the association between periodontitis and preterm birth, but may indicate the dual role of macrophage in both term and preterm delivery. The correlation analysis indicated that MIP1-α concentration in GCF may be related to previous periodontal destruction while its level in placenta may be associated with degree of gingival inflammation.

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Other Titles مستوى بروتين بلعم الإلتهابات ۱ألفا في السائل اللثوي وخلايا المشيمة في مرضى إلتهاب الأنسجة الداعمة الحول سنية مع الولادة المبكرة
Issue Date 2016

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