Oral Tranexamic Acid versus Oral Mefenamic Acid in Reducing Heavy Menstrual Bleeding in Women using Copper IUCD (Cross-over Randomized Controlled Study)
Solafa Mohammad Nour;
Abstract
In this cross-over study included 80 patients complaining from copper IUD induced menorrhagia, fulfilled certain inclusion criteria and divided into two groups (A&B) every group was forty patients:
In the first cycle, both groups were given placebo durg (folic acid)500mg t.d.s(three times daily) and for 5 days.
In the secondcycle group(A)was given tranexamic acid 1 gm t.d.s from the first day of menstrual cycle and for 5 days and group (B) was given mefenamic acid500 mg t.d.s from the first day of menstrual cycle and for 5 days.
In the third cycle the group that was given tranexamic acid was given mefenamic acid, and the group that was given mefenamic acid was given tranexamic acid.
The aim of the study to evaluate and compare the efficacy of haemostatics, in the form of tranexamic acid and mefenamic acid in treating heavy menstrual bleeding in women using copper IUCD.
The study results showed that there was no significant statistical differences in either age, parity, abortion or Occupation of use of copper IUCD between both groups.
The study results showed that there was no significant statistical difference between the two groups regarding Bleeding (days) after treatment with p-value was >0.05
But when compare changes in the mean value of Bleeding (days) we found no significant statistical difference betweenthe baseline and folic acid in both groups with p-value >0.05 and high significant statistical differences in baseline with mefenamic acid and tranexamic acid in both groups with p-value <0.001*.
The results of this study showed that there was no significant statistical difference between both groups regarding napkins/ dayafter treatment with p-value was >0.05.
But when compare changes in the mean value of napkins /day we found no significant statistical difference between the baseline and folic acid in both groups with p-value >0.05 while there were high significant statistical difference between the baseline with mefenamic acid and tranexamic acid in both groups with p-value <0.001*.
the results of this study was that, both tranexamic acid and mefenamic acid are effective medications in decreasing the increased menstrual blood loss in women wearing copper IUD but tranexamic acid was more effective than mefenamic acid in decreasing the amount and number of bleeding days.
In the first cycle, both groups were given placebo durg (folic acid)500mg t.d.s(three times daily) and for 5 days.
In the secondcycle group(A)was given tranexamic acid 1 gm t.d.s from the first day of menstrual cycle and for 5 days and group (B) was given mefenamic acid500 mg t.d.s from the first day of menstrual cycle and for 5 days.
In the third cycle the group that was given tranexamic acid was given mefenamic acid, and the group that was given mefenamic acid was given tranexamic acid.
The aim of the study to evaluate and compare the efficacy of haemostatics, in the form of tranexamic acid and mefenamic acid in treating heavy menstrual bleeding in women using copper IUCD.
The study results showed that there was no significant statistical differences in either age, parity, abortion or Occupation of use of copper IUCD between both groups.
The study results showed that there was no significant statistical difference between the two groups regarding Bleeding (days) after treatment with p-value was >0.05
But when compare changes in the mean value of Bleeding (days) we found no significant statistical difference betweenthe baseline and folic acid in both groups with p-value >0.05 and high significant statistical differences in baseline with mefenamic acid and tranexamic acid in both groups with p-value <0.001*.
The results of this study showed that there was no significant statistical difference between both groups regarding napkins/ dayafter treatment with p-value was >0.05.
But when compare changes in the mean value of napkins /day we found no significant statistical difference between the baseline and folic acid in both groups with p-value >0.05 while there were high significant statistical difference between the baseline with mefenamic acid and tranexamic acid in both groups with p-value <0.001*.
the results of this study was that, both tranexamic acid and mefenamic acid are effective medications in decreasing the increased menstrual blood loss in women wearing copper IUD but tranexamic acid was more effective than mefenamic acid in decreasing the amount and number of bleeding days.
Other data
| Title | Oral Tranexamic Acid versus Oral Mefenamic Acid in Reducing Heavy Menstrual Bleeding in Women using Copper IUCD (Cross-over Randomized Controlled Study) | Other Titles | دراسة عشوائية مقارنة مبنية على مجموعة ضابطة لتحديد أثر العامل المضاد لحال الفبرين (حمض الترانيكساميك) وحمض الميفيناميك عن طريق الفم على تدفق الدم في الحيض في المريضات المستخدمات للولب النحاسي | Authors | Solafa Mohammad Nour | Issue Date | 2015 |
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