Evaluation of Urinary Leukotriene E4 Level and Peak Expiratory Flow Rate in Asthmatic Children Exposed to Passive Smoking

Abstract

P assive smoking is a serious public health problem with particular impact on respiratory health of children. Assessment of ULTE4 level in asthmatic patient is an important test to identify the severity and a marker of exacerbations in asthmatic children. ULTE4 level has a high sensitivity to be a marker of asthmatic patient who exposed to ETS, and it can be used as a marker for differentiation between uncontrolled asthmatic exposed to ETS and uncontrolled asthmatic patients un exposed to ETS. The importance of PEFR as a parameter to be included in the evaluation of asthma control, and identify variables associated with poor asthma control as associated allergic diseases, passive smoking. This study was designed to assess ULTE4 level, PEFR in children suffering from uncontrolled bronchial asthma exposed to passive smoking and compare them with healthy children of same age and sex. This study was performed in the Pediatric Chest Clinic at Children's Hospital, Ain Shams University. The Study was carried out on 90 children, their age ranged between 6-16 years (mean age ± SD =8.5±3.2).