Immunological Relation Of Atopy With Type1 Diabetes in Children
Eman Ibrahim Mohammed;
Abstract
Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic insulin-producing cells. The immune response leading to this destruction is thought to be of the T helper1 (Th1) type, whereas the type of immune response in asthma and atopy is thought to be of the T helper2 (Th2) type. This has raised questions as to whether a decreased risk of asthma and atopy among children with type 1 diabetes is due to the reciprocal effect of Th1and Th2 immune responses.
The aim of the study was conducted to assess immunological relation between atopic disease and type 1 diabetes mellitus using a written questionnaire, It was adopted from American Academy of Dermatology Journal, (March 2008), from 200 children with insulin dependent diabetes mellitus attending pediatric clinic, National Institute of Diabetes , and 200 non diabetic children attending pediatric clinic, New Cairo hospital and it was aided by their relative information, They were chosen by stratified random method.
Results: cases had lower frequency of asthma compared to controls with statistically significant difference between both groups, no allergic conjunctivitis among cases was found but was 2 % among controls, cases had lower frequency of allergic rhinitis compared to controls with statistically significant difference between both groups and cases had lower frequency of atopic dermatitis compared to controls with no statistically significant difference between both groups.
This study shows no statistically significant difference between both groups as regard type of lactation, effect of kind of food in presence of atopical symptoms, exposure to tobacco smoke. This study shows that cases had lower frequency of interference with daily activities; lower frequency of family history of atopy. This study indicates that positive atopical cases had higher frequency of positive family history of atopy compared to negative group with statistically significant difference in between. This study shows that insulin dose among positive atopy cases was lower compared to negative atopy cases group with no significant difference.
Conclusion: patients with T1D have a lower prevalence of atopic symptoms, mainly asthma and allergic rhinitis which is consistent with the Th1/Th2 polarization concept.
Additional studies are needed to evaluate the effect of atopy and allergic diseas
The aim of the study was conducted to assess immunological relation between atopic disease and type 1 diabetes mellitus using a written questionnaire, It was adopted from American Academy of Dermatology Journal, (March 2008), from 200 children with insulin dependent diabetes mellitus attending pediatric clinic, National Institute of Diabetes , and 200 non diabetic children attending pediatric clinic, New Cairo hospital and it was aided by their relative information, They were chosen by stratified random method.
Results: cases had lower frequency of asthma compared to controls with statistically significant difference between both groups, no allergic conjunctivitis among cases was found but was 2 % among controls, cases had lower frequency of allergic rhinitis compared to controls with statistically significant difference between both groups and cases had lower frequency of atopic dermatitis compared to controls with no statistically significant difference between both groups.
This study shows no statistically significant difference between both groups as regard type of lactation, effect of kind of food in presence of atopical symptoms, exposure to tobacco smoke. This study shows that cases had lower frequency of interference with daily activities; lower frequency of family history of atopy. This study indicates that positive atopical cases had higher frequency of positive family history of atopy compared to negative group with statistically significant difference in between. This study shows that insulin dose among positive atopy cases was lower compared to negative atopy cases group with no significant difference.
Conclusion: patients with T1D have a lower prevalence of atopic symptoms, mainly asthma and allergic rhinitis which is consistent with the Th1/Th2 polarization concept.
Additional studies are needed to evaluate the effect of atopy and allergic diseas
Other data
| Title | Immunological Relation Of Atopy With Type1 Diabetes in Children | Authors | Eman Ibrahim Mohammed | Issue Date | 2018 |
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