Protective Role of Lycopene and Grape seed extract against Formaldehyde –induced Pulmonary Damage in Rats.

Abstract

Formaldehyde (FA) is a simplest aldehyde, it is a highly water soluble compound which can rapidly diffuse into many tissues . Due to its high chemical reactivity, the exposure to FA elicits pulmonary cell recruitment and increases microvascular leakage in the upper airways of animals , and increase the production of reactive oxygen species (ROS) and inflammation. The present study aimed to elucidate the protective role of lycopene (lyco.) , grape seed extract (GES) either individually or in combination in mitigating the oxidative stress, inflammatory and apoptotic insults on lung tissue induced by formaldehyde (FA) inhalation in experimental rat model. A total numberof 90 albino rats were used in current study. The animals were classified into nine experimental groups (10 rats /groups) . -The firstGroup: served as negative control group - The second group:rats were exposed to 10 ppm FA for (6 h / day, 5 days/week) for 8 weeks (FA 10 ppm). - The third group: rats wereexposed to 20 ppm FA for (6h / day, 5days/week) for 8 weeks (FA 20 ppm ) - The fourth group:rats wereorally administeredwith lyco in a dose of (10 mg/ kg/5day/ week for 8 weeks) prior exposure to 10 ppm FA by inhalation for (6 h / day , 5days /week) for 8 weeks (FA10PPm+ Lyco.)