Maternal vitamin D level as a risk for early onset neonatal sepsis in term infant
Dina Ahmed Hosney Youssef;
Abstract
Study of the effect of neonatal vitamin D level on early onset neonatal sepsis and the correlation between maternal vitamin D level and neonatal vitamin D level.
The study was conducted between june 2016 and February 2017 at the neonatal intensive care unit Ain shams university hospital after having pediatric department council approval .
Sample size of overal 80 patients (40 patient in each group)was calculated using tpiRQ/C. Program version 2000 based on power of 80% and alpha error 0,05 and a mean of +/- SD of vitamin D 27.1 +/- 8.7 among sepsis group & 21.7 +/- 6.5 among non sepsis group
Group 1:
Forty full term neonates admitted to ASU NICU with the diagnosis of EONS comprise the sepsis group.
Inclusion criteria:
1- Term infant ( > 37 weeks gestation).
2- Early onset neonatal sepsis.
Was diagnosed as sepsis in the first 3 days of life according to Tollnar & Rodwell sepsis score.
Exclusion criteria:
1- Infant with maternal risk factors for sepsis.
2- Infant with congenital anomalies.
3- Mothers with a history of thyroid or parathyroid disease, diabetes.
4- Mothers receiving drugs affecting vitamin D metabolism.
Group 2:
Forty apparently healthy full term neonate attending the outpatient clinic for follow up comprised the control group.
All neonate in the study was subjected to:
1. Detailed history taking:
- Complete obstetric history to detect risk factors of sepsis as (Offensive liquor, PROM >18 hrs, maternal fever >38 C, maternal UTI).
- History of maternal diabetes or pre-eclampsia.
- Mode of delivery, recorded Apgar score.
- Symptoms of sepsis as lethargy and poor feeding.
- Mothers، education, income, duration of sun exposure, vitamin D supplementation during pregnancy (600 IU per day) ,consumption of diary product .
- History of drugs affecting vitamin D metabolism.
- Maternal medical disease (e.g thyroid or parathyroid disease).
2. Careful clinical examination:
- Gestational age assessment .
- Birth weight measurement.
- Detection of clinical signs of sepsis:
1. Respiratory dysfunction (e.g. apnea, signs of respiratory distress).
2. Circulatory dysfunction (e.g. delayed capillary filling, hypotension).
3. GIT dysfunction (e.g. feeding intolerance, abdominal distension, hepatomegaly, jaundice).
4. Neurological dysfunction (e.g. irritability, hypotonia, lethargy).
Patient will be scored according to Tollner & Rodwell sepsis score (Tollner & pohlandt,1976).
The study was conducted between june 2016 and February 2017 at the neonatal intensive care unit Ain shams university hospital after having pediatric department council approval .
Sample size of overal 80 patients (40 patient in each group)was calculated using tpiRQ/C. Program version 2000 based on power of 80% and alpha error 0,05 and a mean of +/- SD of vitamin D 27.1 +/- 8.7 among sepsis group & 21.7 +/- 6.5 among non sepsis group
Group 1:
Forty full term neonates admitted to ASU NICU with the diagnosis of EONS comprise the sepsis group.
Inclusion criteria:
1- Term infant ( > 37 weeks gestation).
2- Early onset neonatal sepsis.
Was diagnosed as sepsis in the first 3 days of life according to Tollnar & Rodwell sepsis score.
Exclusion criteria:
1- Infant with maternal risk factors for sepsis.
2- Infant with congenital anomalies.
3- Mothers with a history of thyroid or parathyroid disease, diabetes.
4- Mothers receiving drugs affecting vitamin D metabolism.
Group 2:
Forty apparently healthy full term neonate attending the outpatient clinic for follow up comprised the control group.
All neonate in the study was subjected to:
1. Detailed history taking:
- Complete obstetric history to detect risk factors of sepsis as (Offensive liquor, PROM >18 hrs, maternal fever >38 C, maternal UTI).
- History of maternal diabetes or pre-eclampsia.
- Mode of delivery, recorded Apgar score.
- Symptoms of sepsis as lethargy and poor feeding.
- Mothers، education, income, duration of sun exposure, vitamin D supplementation during pregnancy (600 IU per day) ,consumption of diary product .
- History of drugs affecting vitamin D metabolism.
- Maternal medical disease (e.g thyroid or parathyroid disease).
2. Careful clinical examination:
- Gestational age assessment .
- Birth weight measurement.
- Detection of clinical signs of sepsis:
1. Respiratory dysfunction (e.g. apnea, signs of respiratory distress).
2. Circulatory dysfunction (e.g. delayed capillary filling, hypotension).
3. GIT dysfunction (e.g. feeding intolerance, abdominal distension, hepatomegaly, jaundice).
4. Neurological dysfunction (e.g. irritability, hypotonia, lethargy).
Patient will be scored according to Tollner & Rodwell sepsis score (Tollner & pohlandt,1976).
Other data
| Title | Maternal vitamin D level as a risk for early onset neonatal sepsis in term infant | Other Titles | العلاقة بين مستوى فيتامين د لدى الام والحدوث المبكر لانتنان الدم لدى حديثي الولادة مكتملي النمو | Authors | Dina Ahmed Hosney Youssef | Issue Date | 2017 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| J 1024.pdf | 2.51 MB | Adobe PDF | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.