Impact of Diabetic Control on Achieving Sustained Virologic Response in Chronic HCV Patients Receiving Direct-Acting Antivirals

Abstract

Epidemiological data have revealed a clear link between HCV infection and disturbed glucose homeostasis. The prevalence of both DM and IR is higher among patients chronically infected with HCV when compared with the general population and those with other causes of chronic liver disease. Both IR and DM are associated with a higher risk for worse outcomes of HCV infection, including progression to fibrosis and cirrhosis and higher risk for development of HCC. The newly introduced DAA regimens have ushered in the era of IFN-free therapy for HCV. These regimens have achieved excellent response rates with SVRs of more than