Estimation of Serum IL-33 Level in Vitiligo and its Relation with the Activity of the Disease
Amany Magd El Din Magd El Din Mohamed;
Abstract
SUMMARY
V
itiligo is a chronic acquired disorder of pigmentation, characterized by destruction of epidermal melanocytes. Prevalence is noticed as being between 0.5 to 1% of general population. Onset of vitiligo occurs in childhood or young adulthood with a peak age at 10–30 years. Both sexes have shown equal predilection for the disease.
Vitiligo is multifactorial rather than being caused by single etiology. Stress, genetic factors, mutations, infection, accumulation of toxic metabolites, altered cellular environment, autoimmunity, and defective melanocyte migration may all interact and lead to the pathogenesis of vitiligo.
It has been reported that cytokines may play a role in depigmentation owing to their alteration of autoimmunity. IL-33 has an important role in different autoimmune diseases, however scarce data are available about its role in vitiligo. In the present study, we aimed to evaluate serum IL-33 levels in active and stable vitiligo patients in comparison to healthy controls in a case control study which was carried out on 75 subjects: 25 patients with active vitiligo, 25 with stable vitiligo and 25 age and sex matched controls. All patients were selected from the dermatology outpatient clinic of vitiligo, Ain-Shams University Hospitals in the period from Septemper 2016 till March 2017.
V
itiligo is a chronic acquired disorder of pigmentation, characterized by destruction of epidermal melanocytes. Prevalence is noticed as being between 0.5 to 1% of general population. Onset of vitiligo occurs in childhood or young adulthood with a peak age at 10–30 years. Both sexes have shown equal predilection for the disease.
Vitiligo is multifactorial rather than being caused by single etiology. Stress, genetic factors, mutations, infection, accumulation of toxic metabolites, altered cellular environment, autoimmunity, and defective melanocyte migration may all interact and lead to the pathogenesis of vitiligo.
It has been reported that cytokines may play a role in depigmentation owing to their alteration of autoimmunity. IL-33 has an important role in different autoimmune diseases, however scarce data are available about its role in vitiligo. In the present study, we aimed to evaluate serum IL-33 levels in active and stable vitiligo patients in comparison to healthy controls in a case control study which was carried out on 75 subjects: 25 patients with active vitiligo, 25 with stable vitiligo and 25 age and sex matched controls. All patients were selected from the dermatology outpatient clinic of vitiligo, Ain-Shams University Hospitals in the period from Septemper 2016 till March 2017.
Other data
| Title | Estimation of Serum IL-33 Level in Vitiligo and its Relation with the Activity of the Disease | Authors | Amany Magd El Din Magd El Din Mohamed | Issue Date | 2018 |
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