THE ROLE OF TRIMETAZIDINE AND ALLOPURINOL IN PREVENTION OF CONTRAST INDUCED NEPHROPATHY AFTER CORONARY ANGIOGRAPHY IN PATIENTS WITH CORONARY ARTERY DISEASE

Abstract

ontrast induced nephropathy (CIN) is defined as is most commonly defined as a 25% increase in serum creatinine from basal level or an absolute increase of at least 0.5 mg/dL that occurs within 48 hours after contrast administration and persisting for two to five days. The most reliable method for the prevention of CIN is through adequate pre-procedural hydration. Other proposed methods include the use of statins, acetylcysteine, sodium bicarbonate infusion and ascorbic acid. Trimetazidine is a metabolic anti-ischemic drug which is proposed to be beneficial in reducing the incidence of CIN. Allopurinol works as an antioxidant drug which is thought to have a beneficial role in reducing the incidence of CIN. The aim of the work is to evaluate the role of trimetazidine and allopurinol in reducing the incidence of CIN following contrast media injection. This study was conducted on 120 patients presented to Ain Shams university hospitals and opting for coronary angiography procedures within the period between February 2017 and August 2017.