Modification Of Cardiac Function In Cirrhotic Patients With Or Without Ascites & Contribution Of Nitric Oxide To Pathogenesis Of Cirrhotic Cardiomyopathy

Abstract

50 male and female subjects divided as 40 patients and 10 controls. The 40 patients were divided into 2 groups the first group were those without ascitis the secnd group were those with ascitis. Personal history was taken to each subject of (hepatitis, surgery, blood transfusion) and full clinical examination.

Laboratory investigations includes complete liver punctions test: AST, ALT, PT, PTT, PC Albumin, proteins, ALP, Total, direct bilirubin. Serum level of nitric oxide.

Echocardiography was done to detect Lt. atrial size, Lt. Vent. end diastolic volume, RT. Vent. size, peqk K, peak A, E/A ratio, EF and diastolic function.

The results was:

Increase Lt. atrial size and Rt. vent. size in 2 cirrhotic patients group (L.C with ascitis more than those without ascites).

Increase LT. Vent. end diastolic volume in 2 cirrhotic patients groups (L.C. with ascitis more than those without ascites). E/A ratio decrease in cirrhotic patients with ascitis more ' ; than those without ascitis. '

Decrease prothlombin concentration in 2 cirrhotic patients groups (and more decrease in cirrhotic with ascitis than those without ascitis).