R0le of Some Testicular Growth Factor in Infertile Males

Abstract

Testis has two main functions, gamete generation and sex hmmone production. These functions are controlled by systemic hormones and local factors. The aim of this study is to asses the possible interrelations between TNF-a, EGF, and IGF-1 and systemic hormonal control system and to assess their role in male infe11ility.

The study was conducted on 70 infe11ile males and 13 age matched fenile group. The study showed that FSH and LH was significantly higher in functional azospemic patients versus the-fertile group. Seminal plasma IGF-1 was sighificantly higher in oligospermic, obstructive and functional azospermic patients versus fertile group. Seminal plasma

TNFo. was significantly higher in obstructive azospermic patients versus the fertile group. Seminal plasma EGF was higher significantly in primary spermatocyte arrest versus the fertile group. Further studies to confirm or to exclude their role in male infe11ility are needed.