Assessment of Programmed Death Receptor Ligand-1 In Chronic Myelogenous Leukemia

Abstract

The aim of this study was to measure plasma levels of the secreted protein Klotho in β-thalassemia major patient and the existence of correlations between the protein level and osteoporosis and fragility fractures. Also, we compared the level of the protein in patients and in healthy controls.50 patients with β-thalassemia major and 30 healthy volunteers were enrolled. Klotho level in plasma was measured by mean of an ELISA test. CBC, Renal functions, Liver functions, Viral markers (HBs Ag, HCV Ab), Calcium, Phosphorus and Serum ferritin level were measured by standard clinical techniques. DEXA was used to measure bone mineral density (BMD) at the lumbar spine (L2–L4) and femoral neck. We found that the Klotho protein concentration was lower in the blood of patients with β-thalassemia major than in healthy controls. Also, the klotho concentration was lower in patients with osteoporosis or osteopenia than those with normal BMD. Also, lower in patients with history of fragility fractures.

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