Cord Albumin As a predictor for Neonatal Jaundice
Ahmed Mohammed Elnahrawy;
Abstract
Jaundice is one of the commonest problems that can occur
in a newborn. Mostly it is physiological in the newborn because
liver is not mature enough to handle the bilirubin .The neonates
have about 1% of uridine diphosphoglucuronosyl transferase
(UDPGT) activity as that of an adult (Kawade and Onishi,
1981).
Apart from this there is an increased load of bilirubin in
neonates as they have a higher circulating erythrocyte volume, a
shorter mean erythrocyte life and a larger early labeled bilirubin
peak (MacDonald et al., 2005).
This hyperbilirubinemia is due to unconjugated bilirubin
which is toxic to central nervous system. More than two thirds
of all newborns appear jaundiced clinically because at some
point during the first week of life almost every newborn has a
total serum bilirubin (TSB) level of > 1 mg/dl, the upper limit
of normal for an adult (0.2-1.2 mg/dl).
There are significant differences in TSB levels in different
populations and it is difficult to define as normal or abnormal or
obtain diagnostic and therapeutic cut off levels (MacDonald et
al., 2005).
Introduction & Aim of the work
2
in a newborn. Mostly it is physiological in the newborn because
liver is not mature enough to handle the bilirubin .The neonates
have about 1% of uridine diphosphoglucuronosyl transferase
(UDPGT) activity as that of an adult (Kawade and Onishi,
1981).
Apart from this there is an increased load of bilirubin in
neonates as they have a higher circulating erythrocyte volume, a
shorter mean erythrocyte life and a larger early labeled bilirubin
peak (MacDonald et al., 2005).
This hyperbilirubinemia is due to unconjugated bilirubin
which is toxic to central nervous system. More than two thirds
of all newborns appear jaundiced clinically because at some
point during the first week of life almost every newborn has a
total serum bilirubin (TSB) level of > 1 mg/dl, the upper limit
of normal for an adult (0.2-1.2 mg/dl).
There are significant differences in TSB levels in different
populations and it is difficult to define as normal or abnormal or
obtain diagnostic and therapeutic cut off levels (MacDonald et
al., 2005).
Introduction & Aim of the work
2
Other data
| Title | Cord Albumin As a predictor for Neonatal Jaundice | Other Titles | نسبه الالبيومين في الحبل السري كوسيله للتنبأ بالصفراء في حديثي الولاده | Authors | Ahmed Mohammed Elnahrawy | Issue Date | 2014 |
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