The Role of Neutrophil-Lymphocyte Ratio in Exacerbation of COPD
Sherif Tayceer Hafez Abu-Serewa;
Abstract
SUMMARY AND CONCLUSION
T
he natural history of chronic obstructive pulmonary disease is characterized by frequent exacerbations. Majority of exacerbations are infectious and bacteria responsible for 30-50% of these cases. The purpose of this study was to determine the benefit of neutrophil/ lymphocyte ratio in acute exacerbations of chronic obstructive pulmonary disease patients in addition to CRP.
The study was a prospective study comprising of 40 cases from outpatient clinic of the Ain-shams University Hospital with an acute exacerbation of COPD.
Periodic isolation and identification and resistant status of pathogens responsible for AECOPD will help us to formulate appropriate treatment protocol and this will be of immense use in reducing mortality and morbidity besides reducing the volume of antibiotics and development of resistance to antibiotics. The protective host immune responses that develop after exacerbation needs to be characterized to facilitate vaccine development. Further, the interaction among different etiologic factors such as environment, bacteria, viruses and atypical pathogens needs to be better understood to treat exacerbations and develop novel as well as cost effective preventive and therapeutic strategies.
T
he natural history of chronic obstructive pulmonary disease is characterized by frequent exacerbations. Majority of exacerbations are infectious and bacteria responsible for 30-50% of these cases. The purpose of this study was to determine the benefit of neutrophil/ lymphocyte ratio in acute exacerbations of chronic obstructive pulmonary disease patients in addition to CRP.
The study was a prospective study comprising of 40 cases from outpatient clinic of the Ain-shams University Hospital with an acute exacerbation of COPD.
Periodic isolation and identification and resistant status of pathogens responsible for AECOPD will help us to formulate appropriate treatment protocol and this will be of immense use in reducing mortality and morbidity besides reducing the volume of antibiotics and development of resistance to antibiotics. The protective host immune responses that develop after exacerbation needs to be characterized to facilitate vaccine development. Further, the interaction among different etiologic factors such as environment, bacteria, viruses and atypical pathogens needs to be better understood to treat exacerbations and develop novel as well as cost effective preventive and therapeutic strategies.
Other data
| Title | The Role of Neutrophil-Lymphocyte Ratio in Exacerbation of COPD | Other Titles | دور نسبة الخلايا المتعادلة الى الخلايا الليمفاوية فى تفاقم اعراض مرض الانسداد الشعبى الهوائي المزمن | Authors | Sherif Tayceer Hafez Abu-Serewa | Issue Date | 2017 |
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