Study of diagnostic value of plasma Malondialdehyde And severity of Portal Hypertension In Egyptian cirrhotic patients

Abstract

Portal hypertension (PH) accounts for the major complications of liver cirrhosis. Early diagnosis of PH is essential for the management of patients with cirrhosis and reduce mortality. Recent guidelines recommend the diagnosis of PH by the measurement of hepatic venous pressure gradient (HVPG) which is an invasive procedure and is only available in specialized centers, so we need to investigate and identify further noninvasive markers for PH. In this study we evaluated plasma Malondialdehyde (MDA), a lipid peroxide marker for oxidative stress, as a diagnostic biomarker for severity of Portal Hypertension in Egyptian cirrhotic patients. This study was conducted on 70 subjects divided into two groups, first group contains 50 subjects suffers from liver cirrhosis and esophageal varices by upper endoscopy while the second group contains 20 healthy subjects. MDA level was higher in Egyptian cirrhotic patient with portal hypertension than in the healthy subjects with significant statistical difference. MDA level increases as the degree of the Ascites increases in the in Egyptian cirrhotic patients with portal hypertension with significant positive statistical correlation.