Doppler Indices of Left Ventricular Diastolic Function in Type II Diabetic Patients

Abstract

Background: Diabetes mellitus characterized by hyperglycemia associated with disturbances of carbohydrate, protein and fat metabolism. With absolute or relative deficiencies in insulin secretion and/ or insulin action. The disease causes significant organ dysfunction with acute and long term complications that results in diabetes related morbidity and mortality. Aim of the Work: To assess gender differences of left ventricular diastolic function by pulsed and tissue Doppler echocardiographic indices in patients with type II diabetes mellitus. Patients sand Methods: This study was conducted in the Cardiology Department (Faculty of Medicine, Ain-Shams University), it was an observational case control study started from December 2015 to July 2016. Patients with type 2 DM were age and sex matched with healthy volunteers as control. The study included 100 patients (40 males and 60 females) with type II Diabetes Mellitus, in addition to 50 (17 males and 33 females). Age and gender matched healthy volunteers as control. Results: The study showed that there is a highly statistically significant difference between study and control groups as regard E/é septal and E/ é lateral with (P=0.002) and (P=0.003) respectively. Conclusion: The study shows there are statistically significant differences of left ventricular diastolic function by pulsed-wave and tissue Doppler echocardiographic indices according to E/E` septal and lateral in patients with type II diabetes mellitus in comparison to non-diabetics. There are insignificant statistical differences in diastolic functions between diabetic males and females. This study might provide important view about differences in left ventricular diastolic dysfunction in diabetic patients free from hypertension and ischemic heart disease. Recommendations: Diabetic patients should be evaluated for subclinical diastolic dysfunction by Doppler studies as well as good control of diabetes for deceleration of the development of clinical cardiomyopathy, and decreased morbidity and mortality. Key words: Diabetes mellitus, Cardiology, insulin secretion, carbohydrate, diastolic heart failure