Recent management of polycystic ovarian syndrome
Ahmed Adly Abdel Fattah;
Abstract
Polycystic ovarian syndrome was first brought to attention by Stein and Letenthal in 1935 who reported a series of seven patients with bilateral polycystic ovaries and thickened ovarian cortex, and clinical features of amenorrhea, hirsutism, infertility and of them were obese.
The 2003 Rotterdam Consensus Workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features of hyperandrogenism and polycystic ovarian morphology.
PCOS is the commonest endocrinopathy in women and most common cause of anovulation and infertility, affecting 5-l 0% of population (Deleo et al., 2003).
PCOS is the commonest endocrinopathy in women, it presents 5-7%
of women of reproductive age (Miriam et al., 2004).
Aetiology of PCOS includes hereditary factors, endocrinological causes and metabolic causes. As regard the hereditary factors, it was stated that the syndrome may be an X-linked dominant inherited disorder. Among the endocrinological causes are hypothalamo-pituitary abnormality, ovarian endocrine abnormality and adrenal abnormality. As regard the metabolic causes, obesity and insulin resistance.
In contrast to the characteristic picture of fluctuating hormone levels in the normal cycle, a steady state of gonadotrophins and sex steroids can be detected in association with persistent anovulation and increased production of androgens.
The polycystic ovary is usually enlarged and is characterized by a smooth pearly white capsule, the surface area is doubled, the number of growing follicle is doubled, the thickness of the tunica is increased and one third increase in cortical stromal thickness.
The 2003 Rotterdam Consensus Workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features of hyperandrogenism and polycystic ovarian morphology.
PCOS is the commonest endocrinopathy in women and most common cause of anovulation and infertility, affecting 5-l 0% of population (Deleo et al., 2003).
PCOS is the commonest endocrinopathy in women, it presents 5-7%
of women of reproductive age (Miriam et al., 2004).
Aetiology of PCOS includes hereditary factors, endocrinological causes and metabolic causes. As regard the hereditary factors, it was stated that the syndrome may be an X-linked dominant inherited disorder. Among the endocrinological causes are hypothalamo-pituitary abnormality, ovarian endocrine abnormality and adrenal abnormality. As regard the metabolic causes, obesity and insulin resistance.
In contrast to the characteristic picture of fluctuating hormone levels in the normal cycle, a steady state of gonadotrophins and sex steroids can be detected in association with persistent anovulation and increased production of androgens.
The polycystic ovary is usually enlarged and is characterized by a smooth pearly white capsule, the surface area is doubled, the number of growing follicle is doubled, the thickness of the tunica is increased and one third increase in cortical stromal thickness.
Other data
| Title | Recent management of polycystic ovarian syndrome | Other Titles | الحديث فى تشخيص وعلاج متلازمة المبيض متعدد التكيسات | Authors | Ahmed Adly Abdel Fattah | Issue Date | 2005 |
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