Effect of Milrinone on Hemodynamic and Left Ventricular Functions During Cardiac Surgery Guided by TEE

Abstract

Although milrinone effectively increases cardiac function, few studies have specifically evaluated its efficacy during cardiac surgery. We investigated the effects of milrinone on hemodynamics and left ventricular function in cardiac surgical patients undergoing mitral valve replacement. Thirty adult patients were studied before and after emergence from cardiopulmonary bypass (CPB). Hemodynamics and transesophageal echocardiogram were recorded while constant filling pressures were maintained by volume reinfusion from CPB reservoir. Twenty-six patients showed hihly significant increases in cardiac output (Co), cardiac index (CI) and fractional area of contraction (FAC) (P value$ < 0.01) with reduction of pulmonary and systemic vascular resistance to the increases were significantly higher at 5 and 15 minutes after loading dose of milrinone. We concluded that milrinone improves hemodynamics and left ventricular function when constant loading conditions are maintained.