DYSLIPlDEMIA AND INSULIN RESISTANCE IN OBESE AND NON-OBESEPOLYCYSTIC OVARIAN SYNDROME (PCOS) WOMEN

Abstract

Tite objectives of this study is to compare the lipid profile , fasting semm insulin and fasting sennn glucose in polycystic ovarian syndrome patients and their weight matched control .

Titis study was done at: Kasr AL Aini Hospital and Ahmed Maher Teaching Hospital.

Tite nwnber of patients parttctpating in the study : 20 infertile women grouped into 2 !,'I'Oups: the control group (10 infertile non PCOS patients) and the PCOS !,'I'Oup (I 0 PCOS patients) subclassified into obese and non-obese according to their body mass index

Tite main priciple was to measure: Total cholesterol level, triglycerides, low density lipoprotein, high density lipoprotein, fasting insulin and fasting glucose levels.

Statistical analysis of the data proved that female with polycystic ovarian syndrome have dyslipidemia, hyperinsulinemia and insulin resistance compared to their control group and more pronounced in obese when compared with non-obese patients.

TI1e results of this study were: Highly significant (p< 0.01)

Higher mean serum cholesterol in PCOS patients 209.90 ± 32.89 mg/dl compared to the control 178.40 ± 32.00 mg/dl.

Higher mean sennn triglyceride in PCOS patients 149.40 ± 38.87 mg/dl compared to the control I 09.25 ± 38.48 mg/dl.

Lower mean serum high density lipoprotein in PCOS patients 41.26 ± 6.85 mg/dl compared to the control 58.20 ± 4.59 mg/dl.

Higher mean semm low density lipoprotein in PCOS patients 138.70 ± 30.31 mg/dl compared to the control 98.35 ± 30.26 mg/dl.