The Correlation Between Serum Testosterone Level and Sarcopenia in Egyptian Male Patients With Liver Cirrhosis

Abstract

hronic liver disease (CLD) is defined as the continuity of clinical and biochemical evidence of hepatic dysfunction for longer than six months Cirrhosis results from different mechanisms of liver injury that lead to necroinflammation and fibrogenesis; histologically it is characterized by diffuse nodular regeneration surrounded by dense fibrotic septa with subsequent parenchymal extinction and collapse of liver structures, together causing pronounced distortion of hepatic vascular architecture Although Cirrhosis results from different mechanisms of liver injury such as (viral hepatitis, autoimmune, Wilson disease, hemochromatosis, non-alcoholic cirrhosis, drug induced….etc.), chronic viral hepatitis (HBV,HCV) is considered the most important cause of liver disease in Egypt because of high prevalence rate of hepatitis C virus (HCV) in the general Egyptian population, HCV is considered the major risk factor for cirrhosis Androgens are important anabolic hormones produced predominantly in the testes, with effects on muscle, haematopoiesis, metabolism and sexual function. Low circulating testosterone levels in men are associated with anaemia, osteoporosis, insulin resistance and increased all-cause mortality.