Study of Additional Chromosomal Abnormalities in Young Adult Egyptian Chronic Myeloid Leukemia Patients
Asmaa Mohammed Elsayed Eissa;
Abstract
Recent interest in additional chromosomal abnormalities (ACAs) in chronic myeloid leukemic patients is now gaining more importance particularly in progressive disease.
The appearance of these ACAs during treatment is commonly known as clonal evolution (CE) and seems to play an important role in imatinib mesylate resistance; The World Health Organization (WHO) classification suggests that those patients showing ACAs emerging during treatment should be considered in accelerated phase (AP). The European Leukemia Net (ELN) recommendations suggest that the presence of ACAs at diagnosis may represent a "warning" feature, requiring careful monitoring of the patient.
The most frequent aberrations detected in advanced CML were trisomy 8, (+8) a second Ph chromosome, and a partial trisomy of the long arm with partial monosomy of the short arm of chromosome 17 [isochromosome (17) (q10)], vanishing Y chromosome (−Y), monosomy 7 (−7), +19, +21, +17, which were designated “major-route of karyotypic evolution”, While ACAs that were rarely observed in AP or BC, such as t (3;12), t (4;6), t (2;16), and t (1;21), we
The appearance of these ACAs during treatment is commonly known as clonal evolution (CE) and seems to play an important role in imatinib mesylate resistance; The World Health Organization (WHO) classification suggests that those patients showing ACAs emerging during treatment should be considered in accelerated phase (AP). The European Leukemia Net (ELN) recommendations suggest that the presence of ACAs at diagnosis may represent a "warning" feature, requiring careful monitoring of the patient.
The most frequent aberrations detected in advanced CML were trisomy 8, (+8) a second Ph chromosome, and a partial trisomy of the long arm with partial monosomy of the short arm of chromosome 17 [isochromosome (17) (q10)], vanishing Y chromosome (−Y), monosomy 7 (−7), +19, +21, +17, which were designated “major-route of karyotypic evolution”, While ACAs that were rarely observed in AP or BC, such as t (3;12), t (4;6), t (2;16), and t (1;21), we
Other data
| Title | Study of Additional Chromosomal Abnormalities in Young Adult Egyptian Chronic Myeloid Leukemia Patients | Authors | Asmaa Mohammed Elsayed Eissa | Issue Date | 2018 |
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