Comparison between Endometrial Volume Assessed by VOCAL versus Office Hysteroscope for Diagnosis of Endometrial Polyps

Abstract

T Background: To compare hysteroscopy, two dimensional transvaginal ultrasound (2D VUS), three dimensional (3D) Virtual Organ Computer-aided AnaLysis™ to detect endometrial polyps (EP) in premenopausal women with abnormal uterine bleeding (AUB).

Methods: A prospective study was done at Ain Shams Maternity Hospital, Egypt from March 5th 2015 to December 30th 2015; enrolling 118 premenopausal women with AUB. 2D TVUS, 3D VOCAL and hysteroscopy were done.

Results: 109 patients reached final analysis. 36 women (33%) were diagnosed with EP by 2D TVUS. 50 (45.9%) had EP by hysteroscopy. Endometrial thickness was 10.1mm by 2D TVUS and endometrial volume was 4.92ml by VOCAL in women with EP by hysteroscopy compared to 9.9mm and 3.50ml in women with no EP respectively (P=0.223; P=0.06). 2D TVUS has sensitivity, specificity, positive and negative predictive values of 54%, 84.7%, 75% and 68.5% respectively. Endometrial thickness of >7.5mm has sensitivity, specificity, positive, negative predictive values and overall accuracy of 82%, 37.3%, 52.6%, 71% and 57.8% respectively. Endometrial volume of >1.2ml has sensitivity, specificity, positive, negative predictive values and overall accuracy of 90%, 42.4%, 57%, 83.3%, and 64.2% respectively.