Evaluation of Serum Lipoxin A4 in Exercise Induced Asthma

Abstract

Exercise-induced asthma is asthma that is triggered by vigorous or prolonged exercise or physical exertion. Most people with chronic asthma experience symptoms of asthma during exercise. The symptoms of exercise-induced asthma generally begin within 5 to 20 minutes after the start of exercise, or 5 to 10 minutes after brief exercise has stopped and diagnosed by reduction of > 15% of expected FEV1. Lipoxins (LXs) are lipoxygenase (LO)–derived products of arachidonic acid, that are predominately generated during cell-cell interactions at sites of vascular or tissue inflammation The aim of this study is to detect the level of lipoxin A4 in asthmatic patients and in EIA. The study was conducted on 90 children; 45 asthmatic patients who were recruited from both Allergy and Immunology clinic and Chest clinic Children´s hospital, Ain Shams, and 45 healthy non asthmatic non