A STUDY OF SERUM CERULOPLASMIN IN PATIENTS WITH DIABETIC NEPHROPATHY AND ITS VALUE AS A MARKER OF CARDIOVASCULAR DISEASE

Hend Ramadan Abdallah


Abstract


Diabetes mellitus consider one of the most frequent chronic diseases worldwide, being among the top five main causes of death in developed countries. It is also becoming epidemic in developing countries with type 2 diabetes mellitus is the most prevalent form of the disease, representing 90% to 95% of cases. Despite ceruloplasmin (CP) has antioxidant properties being has ferroxidase activity in that it oxidize the more toxic ferrous ions to the less toxic ferric form, elevated circulating CP is associated with cardiovascular disease (CVD). This is possible due to the capacity of CP to promote vasculopathic effects that include lipid oxidation, negation of nitric oxide bioactivity and endothelial cell apoptosis This study was case control study, included thirty patients with type 2DM recruited from the nephrology department of new EL Kasr El-Aini hospital in period between April to November 2014 & twelve normal volunteers as a control group. Subjects divided into three groups, group (A) includes fifteen patients with diabetic nephropathy but without ischemic heart disease, group (B) includes fifteen patients with diabetic nephropathy and ischemic heart disease and group (C) as control group.


Other data

Other Titles دراسة بلازما سيرولوبلازمين في المرضي الذين يعانون من اعتلال الكلي السكري وقيمته كعلامه من أمراض القلب و الشرايين
Issue Date 2016
URI http://research.asu.edu.eg/handle/12345678/2548


File SizeFormat 
G12410.pdf983.11 kBAdobe PDFView/Open
Recommend this item

CORE Recommender

Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.