Plasma Tissue Factor Level And Its Relation To The Degree Of Myocardial Damage In Cases Of Acute Myocardial Infarction
Nasser AbdAllah Ahmed Salem;
Abstract
Intracoronary thrombus formation is thought to play an important role in the genesis of acute myocardial ifnarction.
Although the factors precipitating coronary thrombosis have not yet been fully elucidated, activation of thrombin is an event common to thrombosis in general.
Hypercoagulability has been reported to be associated with acute myocardial infarction and angina pectoris which may be induced by TF expression on circulatinng monocytes.
TF is a low molecular weight glycoprotein that serves as primary initiator of extrinsic coagulation cascade and major regulator of coagulation, hemostasis and thrombosis, therefore TF is the major source of thrombin production in vivo and may play an important role in the pathogenesis of ischemic coronary syndromes by mediating intravascular thrombosis.
The aim of this work is to determine the relationship between myocardial ischemia and procoagulant acitivity in AMI patients and to correlate between TF level and both pattern of onset and degree of myocardial damage in AMI patients.
Although the factors precipitating coronary thrombosis have not yet been fully elucidated, activation of thrombin is an event common to thrombosis in general.
Hypercoagulability has been reported to be associated with acute myocardial infarction and angina pectoris which may be induced by TF expression on circulatinng monocytes.
TF is a low molecular weight glycoprotein that serves as primary initiator of extrinsic coagulation cascade and major regulator of coagulation, hemostasis and thrombosis, therefore TF is the major source of thrombin production in vivo and may play an important role in the pathogenesis of ischemic coronary syndromes by mediating intravascular thrombosis.
The aim of this work is to determine the relationship between myocardial ischemia and procoagulant acitivity in AMI patients and to correlate between TF level and both pattern of onset and degree of myocardial damage in AMI patients.
Other data
| Title | Plasma Tissue Factor Level And Its Relation To The Degree Of Myocardial Damage In Cases Of Acute Myocardial Infarction | Other Titles | مستوى عامل الأنسجة فى البلازما وعلاقته بدرجة اصابة عضلة القلب فىى حالات الاحتشاء الحاد لعضلة القلب | Authors | Nasser AbdAllah Ahmed Salem | Issue Date | 2002 |
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