CYTOGENETIC EFFECTS OF "MALATHION'' AND "PIRIMIPHOS-METHYL" RESIDUES IN "' STORED WHEAT IN MICE

Abstract

The cytogenetic effect of malathion and "Pirimiphos-methyl residues in wheat grains stored for different periods of time (4, 12, 24 weeks) was evaluated in Swiss mice for: 1- Chromosomal aberrations analysis in bone-marrow and spermatocyte cells. 2- Chromosomal aberrations and sister chromatid exchange (SEC) analysis in spleen cell culture from mice fed with stored wheat grains. 3- Cytogenetic studies on the different tissues of the F 1 generation obtained from mice fed on treated wheat grains. The tested doses were 8.36, 25.08 and 41.80 mg malathion kg- 1 and 8.75, 26.25 and 43.75 mg "Pirimiphos-methyl" kg- 1 wheat grains. The cytogenetic effect induced in the different mouse tissues by the residue of the two insecticides was dose dependent and increased with increasing of both feeding and storage periods.