Serum and Urinary Angiotensinogen in Children with Chronic Kidney Disease

Abstract

T his study was carried out in Pediatric Conservative Nephrology clinic, Children's Hospital, Ain Shams University in the period from January to September 2015. The study was conducted on 45 children, 35 patients with chronic kidney disease following up at the pediatric conservative nephrology clinic, Children's Hospital, Ain Shams University, and 10 age & sex matched healthy children serving as control group.  Group I (cases): included 35 patients with chronic kidney disease with glomerular filtration rate (GFR) < 60 ml/min/1.73m² & duration of the disease not less than 6 months. (29 males & 6 females), their ages ranged from 1 year up to 14 years with mean age 5.1 ± 3.3 years.  Group II (controls): included 10 apparently healthy age & sex matched children (7 males & 3 females). their ages ranged from 2 years to 10 years with mean age 5.3 ± 3.1 years. All patients were subjected to detailed history taking, laying stress on medication history, thorough physical examination with special emphasis on: blood pressure measurement, weight, height & body mass index (BMI). Lab investigations included: complete blood count (cbc), serum creatinine & corrected creatinine clearance. Serum and urinary angiotensinogen were measured for each patient enrolled in the study as well as the control group using Human Angiotensinogen ELISA kits.