Synthesis and biological evaluation of some heterocyclic compounds as antiviral

Abstract

The chemistry of 2(3H)- furanones had received great attention in the last decades. The importance of these compounds is due to facile opening of the furanone ring to give acyclic products which can recyclize again to afford a variety of heterocyclic systems of synthetic and biological importance e.g pyrrolones, pyridazinones, isothiazolones, oxadiazoles .etc. The original work of this thesis can be classified into three parts: Part 1: In this part, the acid hydrazide derivative 1 bearing 1,3-diphenyl-pyrazolyl moiety at position-3 was prepared, and utilized for the construction of pyridazine, pyridazinone, pyrazole, pyrazolone, phthalazinedione and schiff bases upon condensation with different carbonyl compounds. Part 2: In this part, the behavior of the previous hydrazide derivative towards carbon disulphide to form potassium dithiocarbamate salt was studied. The later salt was converted to pyridazinotriazole, triazolothiadiazole and triazolothiadiazine derivatives as examples of fused heterocyclic compounds. The structures of the newly synthesized compounds in parts 1 &2 were established on the basis of IR, 1H-NMR, mass spectral data, and elemental analyses. Part 3: Biological activity part: In this part, All the prepared compounds were evaluated against highly pathogenic avian influenza H5N1 after doing the toxicity test to all concentrations prepared after excluding the toxic concentrations. Some of the tested compounds showed promising activities.