Correlation between Mean Platelet Volume and different morbidities in preterm infants
Michael Nabil Halim;
Abstract
reterm birth is an increasingly common complex condition with multiple risk factors and has substantial medical, psychological, economic and social impacts.
It is the leading cause of infant mortality in both developing and developed countries. It is also the most important determinant of short and long term morbidity in infants and children, and can have serious long term health consequences.
There is increasing in the survival ofpreterm infants due to the improvement in skills and technologies used in theirmanagement.
Our study is a prospective study which took place in the neonatal intensive care unit, Faculty of Medicine, Ain Shams University.
The aim of the work was to assess the correlation between mean platelet volume and the occurrence of various morbidities of prematurity; early neonatal sepsis, necrotizing enterocolitis and intraventricular hemorrhage.
The total number of the studied cases was 50 preterm. 20 of them were males (40%) and 30 were females (60%). Their gestational age ranged from 29 to 36 weeks, and their birth’s weight varied from 0.7 to 3.1 Kg. the commonest causes of prematurity were premature rupture of membrane and preterm labor (48% each) while accidental hemorrhage occurred in only 4% of cases.
The majority of the complicated cases had neonatal sepsis (15 preterm); only one patient had necrotizing enterocolitis while only one preterm died. There was direct relationship between duration of NICU admission and occurrence of sepsis.
All the neonates in our study were examined clinically at birth and were followed up during the duration of NICU admission. Neonatal sepsis, necrotizing enterocolitis and intraventericular hemorrhage were reported in the studied preterms. Also CBC and MPV were done to all the included preterms on day one and day three of life.
The included preterms where divided clinically into 3 groups; no morbidity (34 preterm), sepsis (15 preterm) and NEC group (1 preterm).
Total leucocytic count, hemoglobin and platelet count were less in sepsis group than in no morbidity group. They were also lower in day three than on day one among the sepsis group.
The most significant changes in CBC were platelet count and MPV. Platelet count was observed to be significantly lower on day three in those preterms with neonatal sepsis than in no morbidity group.
As regard MPV it was also found to be lower on day one among those preterms who developed early onset neonatal sepsis later on.
It is the leading cause of infant mortality in both developing and developed countries. It is also the most important determinant of short and long term morbidity in infants and children, and can have serious long term health consequences.
There is increasing in the survival ofpreterm infants due to the improvement in skills and technologies used in theirmanagement.
Our study is a prospective study which took place in the neonatal intensive care unit, Faculty of Medicine, Ain Shams University.
The aim of the work was to assess the correlation between mean platelet volume and the occurrence of various morbidities of prematurity; early neonatal sepsis, necrotizing enterocolitis and intraventricular hemorrhage.
The total number of the studied cases was 50 preterm. 20 of them were males (40%) and 30 were females (60%). Their gestational age ranged from 29 to 36 weeks, and their birth’s weight varied from 0.7 to 3.1 Kg. the commonest causes of prematurity were premature rupture of membrane and preterm labor (48% each) while accidental hemorrhage occurred in only 4% of cases.
The majority of the complicated cases had neonatal sepsis (15 preterm); only one patient had necrotizing enterocolitis while only one preterm died. There was direct relationship between duration of NICU admission and occurrence of sepsis.
All the neonates in our study were examined clinically at birth and were followed up during the duration of NICU admission. Neonatal sepsis, necrotizing enterocolitis and intraventericular hemorrhage were reported in the studied preterms. Also CBC and MPV were done to all the included preterms on day one and day three of life.
The included preterms where divided clinically into 3 groups; no morbidity (34 preterm), sepsis (15 preterm) and NEC group (1 preterm).
Total leucocytic count, hemoglobin and platelet count were less in sepsis group than in no morbidity group. They were also lower in day three than on day one among the sepsis group.
The most significant changes in CBC were platelet count and MPV. Platelet count was observed to be significantly lower on day three in those preterms with neonatal sepsis than in no morbidity group.
As regard MPV it was also found to be lower on day one among those preterms who developed early onset neonatal sepsis later on.
Other data
| Title | Correlation between Mean Platelet Volume and different morbidities in preterm infants | Other Titles | العلاقة ما بين متوسط حجم الصفائح الدموية و الأمراض المختلفة في الأطفال المبتسرين | Authors | Michael Nabil Halim | Issue Date | 2014 |
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