Single dose versus multiple day antibiotic prophylaxis for cesarean section: Randomized controlled trial

Abstract

The most commonly performed major surgical procedure is cesarean section, as there is an increase in the incidence of cesarean delivery (CD) In current study we compare the efficacy of administration of prophylactic antibiotic single dose versus multiple day dose in reducing post-operative surgical site infection in women undergoing elective cesarean section. The study was conducted in Ain Shams University Maternity Hospital; Cairo during the period from December2015 to October 2016. This Study comprised 330 women undergoing elective cesarean delivery. Wound infection was the most common postpartum complication in both groups, The percentage of wound infection was less frequent in group B(control group) than group A(study group), but with no statistically significant difference(P. value=.925).There was no difference in both groups regarding post operative fever (p –value .285), endometritis, post operative UTI and hospital readmission. Key words Cost-benefit ratio should be in mind especially if the same efficacy was achieved by low cost regimen and dose. There is a recommendation to extend the trial to parturient of high risk for infection.