Evaluation of Gastroesophageal Reflux Disease in Neonates Using Combined Esophageal Multichannel Intraluminal Impedance and PH Monitoring

Abstract

Gastroesophageal reflux is a normal physiologic process occurring several times per day in healthy infants, most episodes of GER lasts <3 minutes, occur in the postprandial period, and cause few or no symptoms. In contrast, GERD is present when the reflux of gastric contents causes troublesome symptoms and /or complications. Multichannel esophageal impedance and PH monitoring represents a useful tool in the assessment of neonatal gastroesophageal reflux disease and assessing the response to antireflux treatment. The aim of the study is to evaluate the gastroesophageal reflux disease in neonates pre and post proton pump inhibitor therapy using multichannel intraluminal esophageal impedance and PH monitoring. We have recruited 20 neonates from Ain Shams University hospitals with symptoms and signs suggestive of GERD