Prevalence of Celiac disease in clinically diagnosed diarrhea predominant IBS Egyptian patients

Abstract

Irritable bowel syndrome {IBS} is defined according to Rome III consensus as a clinical syndrome characterized by presence of abdominal pain or discomfort, at least 3 days per month in the last 3 months, and two or more other symptom features; improvement with defecation, association with a change in stool frequency and association with a change in stool form or appearance. Celiac disease (CD) is a condition traditionally characterized by chronic inflammation of proximal small intestine resulting in villous atrophy and malabsorption that can genetically develop in susceptible individuals ingesting gluten which is prevalent in wheat, barley, and rye. IBS is a collection of a diverse grouping of symptom defined syndromes, celiac disease may also present with a wide spectrum of both gastrointestinal (GI) and non GI symptoms, many of which bear a large degree of overlap with IBS. A systemic review and meta analysis has concluded that celiac disease, as diagnosed by positive serology and positive biopsy, was four folds more prevalent among patients with a clinical presentation of IBS than in non IBS populations.