THE PROTECTIVE EFFECT OF SOME NATURAL PRODUCTS ON GENE EXPRESSION AND CHROMOSOMAL ABERRATIONS INDUCED BY THIOACETAMIDE IN MALE ALBINO RATS

Abstract

Liver fibrosis is a common sequel to diverse liver injuries. Without effective treatments, reversible liver fibrosis at an early stage leads to irreversible cirrhosis. Chronic liver injury leads to a progressive wound healing response that eventually results in liver fibrosis characterized by both quantity and quality alteration of hepatic extracellular matrix, ECM. Moreover, liver fibrosis represents the response of the liver to diverse chronic insults such as parasitic disease, chronic viral infection (hepatitis B and C), immunologic attack (autoimmune hepatitis), hereditary metal overload, toxic damage, and so forth.Because of the worldwide prevalence of these insults, liver fibrosis is common and is associated with significant morbidity and mortality.

The present study aimed to explore the efficacy of Boswellia serrata gum extract and Punica granatum peelextract in regression of liver fibrosis induced by thioacetamide in adult male albino rats.