BIOCHEMICAL STUDIES OF SOME BLOOD OXIDANTS AND ANTIOXIDANTS OF CURRENT CIGARETTE SMOKERS
Hanaa Fakhry Salib;
Abstract
Cigarette smoking is one of the major public problems of our times. It kills over
400.000 people a year, making it the largest principle cause of death and disability in developed countries for example, atherosclerosis, emphysema, obstructive lung disease,
neoplastic disorder and different types of cancer lung, larynx, oral cavity and esophagus, also cigarette smoking associated with psoriasis, periodontal bone less, hemorrhagic stroke, male fertility and schizophrenia.
Cigarette smoke is a heterogeneous mixture of gases, uncondensed vaporous, liquid particulate matter produced by incomplete combustion of tobacco leaf. The stream of cigarette smoke consists of side stream and main stream, for example: nicotine which found in all forms of tobacco and absorbed from tobacco smoke in the lungs leading to destruction of some neurotransmitter functions ex, dopamine (DA), norepinephrine (NE), serotonin and glutamate.
Polycyclic aromatic hydrocarbons which considered as a carcinogenic compounds leads to cancer in many organs.
Carbon monoxide (CO) is a non-irritating gas resulting from incomplete combustion of organic matters and enhances the development of atherosclerosis and has damaging effect on the myocardium.
The oxidative stress is defmed as a pathophysiologic condition, caused by an imbalance between reactive oxygen species (ROS) and antioxidant in favour to the former with increase of formation of peroxidation products.
Antioxidants are compounds that inhibit lipid peroxidation by interfering with the chain reaction of peroxidation and/or by scavenging oxygen radicals. Antioxidants opposite the toxic actions oflipid peroxide and oxygen radicals.
This study was carried out to show the effect of different duration and intensity of cigarettes on some biochemical aspects in cigarette smokers.
This study was planned to evaluate the effect of cigarette smoking on the level of some lipid parameters serum total cholesterol, triglycerides, lipoprotein-cholesterol fraction (LDL/HDL, Ch!HDL), some antioxidants Vit. C (ascorbic acid), Vit. E (a tocopherol) and SOD (superoxide dismutase) and malonyldialdehyde MDA as oxidant.
This study was made on about ninety subjects; they were divided into 3 groups according to
1- Smoker age.
2- Number of cigarette/day.
3- Smoking duration.
400.000 people a year, making it the largest principle cause of death and disability in developed countries for example, atherosclerosis, emphysema, obstructive lung disease,
neoplastic disorder and different types of cancer lung, larynx, oral cavity and esophagus, also cigarette smoking associated with psoriasis, periodontal bone less, hemorrhagic stroke, male fertility and schizophrenia.
Cigarette smoke is a heterogeneous mixture of gases, uncondensed vaporous, liquid particulate matter produced by incomplete combustion of tobacco leaf. The stream of cigarette smoke consists of side stream and main stream, for example: nicotine which found in all forms of tobacco and absorbed from tobacco smoke in the lungs leading to destruction of some neurotransmitter functions ex, dopamine (DA), norepinephrine (NE), serotonin and glutamate.
Polycyclic aromatic hydrocarbons which considered as a carcinogenic compounds leads to cancer in many organs.
Carbon monoxide (CO) is a non-irritating gas resulting from incomplete combustion of organic matters and enhances the development of atherosclerosis and has damaging effect on the myocardium.
The oxidative stress is defmed as a pathophysiologic condition, caused by an imbalance between reactive oxygen species (ROS) and antioxidant in favour to the former with increase of formation of peroxidation products.
Antioxidants are compounds that inhibit lipid peroxidation by interfering with the chain reaction of peroxidation and/or by scavenging oxygen radicals. Antioxidants opposite the toxic actions oflipid peroxide and oxygen radicals.
This study was carried out to show the effect of different duration and intensity of cigarettes on some biochemical aspects in cigarette smokers.
This study was planned to evaluate the effect of cigarette smoking on the level of some lipid parameters serum total cholesterol, triglycerides, lipoprotein-cholesterol fraction (LDL/HDL, Ch!HDL), some antioxidants Vit. C (ascorbic acid), Vit. E (a tocopherol) and SOD (superoxide dismutase) and malonyldialdehyde MDA as oxidant.
This study was made on about ninety subjects; they were divided into 3 groups according to
1- Smoker age.
2- Number of cigarette/day.
3- Smoking duration.
Other data
| Title | BIOCHEMICAL STUDIES OF SOME BLOOD OXIDANTS AND ANTIOXIDANTS OF CURRENT CIGARETTE SMOKERS | Other Titles | دراسات بيوكيميائية على بعض المؤكسدات ومضادات الأكسدة فى دم المدخنين | Authors | Hanaa Fakhry Salib | Issue Date | 2006 |
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